SKU: 11266624835

Shedding, Haaren

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Description

Shedding, HaarenReduzierter Haarausfall (MC5R) ist ein komplexes genetisches Merkmal, das alle Rassen betreffen kann und epistatische Wechselwirkungen mit FGF5 (Felllnge) und RSPO2 (Fellbeschaffenheit) hat, die ebenfalls die Haarmorphologie bei Hunden beeinflussen. Diese Loci haben aufgrund einer starken knstlichen Selektion fr das Fellphnotyp selektive Sweeps durchlaufen. Die MC5R Proteinsequenz ist evolutionr bei Sugetieren konserviert, und eine bestimmte Mutation

Reduzierter Haarausfall (MC5R) ist ein komplexes genetisches Merkmal, das alle Rassen betreffen kann und epistatische Wechselwirkungen mit FGF5 (Felllänge) und RSPO2 (Fellbeschaffenheit) hat, die ebenfalls die Haarmorphologie bei Hunden beeinflussen. Diese Loci haben aufgrund einer starken künstlichen Selektion für das Fellphänotyp selektive Sweeps durchlaufen. Die MC5R-Proteinsequenz ist evolutionär bei Säugetieren konserviert, und eine bestimmte Mutation verursacht eine konformationale Änderung in der Tertiärstruktur des Proteins, das an der Produktion von Talg beteiligt ist, was die Wasserabweisung und Thermoregulation beeinflusst und zu erhöhtem Haarausfall führen kann. Der Gentest kann das Ausmaß des Haarausfalls bei einem Hund offenbaren, was helfen kann, geeignete Hunde für die Zucht auszuwählen und den Haarausfall zu reduzieren. Da einzelne Gene nur Durchschnittswerte für den Haarausfall liefern, ist es fast notwendig, die Kombination der Gene MC5R und RSPO2 zu testen.

Im Folgenden sind 3 Tabellen aufgeführt, die das Ausmaß des Haarausfalls je nach Genotyp zeigen; die letzte veranschaulicht das Ausmaß des Haarausfalls je nach Genotypkombination von MC5R und RSPO2.

MC5R

Genotyp

Grad des Haarausfalls

SD/SD

Niedrig

SD/N

Moderat

N/N

Hoch

N – Wildtyp-Allel, SD - Variantenallel

Hunde mit einem oder zwei Kopien der Variantenallele verlieren weniger Haare als Hunde ohne Kopien.

RSPO2

Genotyp

Grad des Haarausfalls

F/F

Niedrig

F/N

Moderat

N/N

Hoch

F/F - Fellbeschaffenheit, N/F - Fellbeschaffenheit, N/N - unzureichendes Fell

KOMBINATION VON MC5R UND RSPO2

Genotyp MC5R

Genotyp RSPO2

Grad des Haarausfalls

SD/SD

F/F

0

SD/SD

F/N

1

SD/SD

N/N

2

SD/N

F/F

1

SD/N

F/N

2

SD/N

N/N

3

N/N

F/F

2

N/N

F/N

3

N/N

N/N

4

Grade des Haarausfalls: niedrig 0 < 1 < 2 < 3 < 4 hoch

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SKU: 11266624835

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4.1 ★★★★★
Based on 28 reviews
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Rosa Mendoza
Pawtucket, US
★★★★★ 5
Compound gpl1 girls beware of this otherwise perfect multi
Love this but I can’t take anymore, I am on glp1 with b6 and I started breaking out in hives, after some research I realized that the rash was a niancin rash!!! The b6 in the compound and the b6 in the multi was too much! Aka is backfired on me but this stuff works! I love carlyle! So girlies who are on compound tirzep… we can add extra b vitamins to our compound. Can’t wait to try to get a non compounded so I can enjoy this product!!!
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Reviewed in the United States on February 25, 2026
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elisot
Carnegie, US
★★★★★ 5
Good
I love these! They have a little smell to them but my stomach favors these types of vitamins rather than the chalky ones.
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Reviewed in the United States on March 19, 2026
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Verified Purchase
Mickey
Charlottesville, US
★★★★★ 5
Good pain relief. Fair price and no side effects.
Size: 30 Count (Pack of 1)
I take this for its ability to block interleukin 1b and interleukin 6 and cox 1 and 2 enzymes without side effects or harm to liver or kidneys. This brand seems to be working well. I tried the Hawaii brand BioAstin 90 caps for $48 and this brand seems to be about the same price per cap. I have not noticed any difference in quality. Information: Astaxanthin works as an anti-inflammatory through multiple pathways. The various mechanisms of action for Astaxanthin as an anti-inflammatory have been demonstrated in several studies (Lee, et al, 2003; Ohgami, et al, 2003; Choi, et al, 2008; Kishimoto, et al, 2010). This research has consistently shown that Astaxanthin works on a variety of different causes of inflammation. In fact, there is evidence that it works on six different inflammatory markers, but that it works in a gentle, broad-spectrum manner. This is in distinct contrast to anti-inflammatory drugs such as Celebrex® and Vioxx® as well as over-the-counter anti-inflammatories such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs including Tylenol®, Motrin®, Alleve®, etc.) and aspirin, all of which target a single inflammatory marker, but in an intense manner. Inflammatory markers gently reduced by Astaxanthin include: • Prostaglandin E-2 • Interleukin 1b • Interleukin 6 • Tumor Necrosis Factor-A • Nitric Oxide et al, 2010) • Cox 1 & 2 enzymes (Lee, et al, 2003; Ohgami, et al, 2003; Choi, et al, 2008; Kishimoto, Natural Astaxanthin has never been reported to have any side effect or contraindication in hundreds of medical research studies as well as over 15 years of commercial consumer use.
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Reviewed in the United States on February 11, 2026
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clover
Massapequa, US
★★★★★ 5
Astaxanthin
Size: 30 Count (Pack of 1)
1 week - I've been taking this 12mg Astaxanthinand I've experienced no side effects. I've made sure to take this with food. My husband tried it twice and had a stomach ache afterwards, but I've been fine! I'm looking forward to seeing if this supplement helps with my dry eyes & gives me a glow/tan. Will provide an update in a month.
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Reviewed in the United States on April 2, 2026
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yamileth
Port Orchard, US
★★★★★ 4
Un buen producto en buen estado.
Size: 30 Count (Pack of 1)
Es buen producto con ingredientes confiables, se pueden ver los cambios en menos de 30 dias. El producto llego en el tiempo prometido y en buen estado.
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Reviewed in the United States on March 12, 2026

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