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Description
Fascin Recombinant Rabbit mAb (SDT-759-13)Product Specification Host Rabbit Antigen Fascin Synonyms 55 kDa actin bundling protein, Singed like protein, p55, FSCN1, FAN1, HSN, SNL Immunogen Recombinant Protein Location Cytoplasm Accession Q16658 Clone Number SDT 759 13 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP Reactivity Hu, Ms Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | Fascin |
| Synonyms | 55 kDa actin-bundling protein, Singed-like protein, p55, FSCN1, FAN1, HSN, SNL |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | Q16658 |
| Clone Number | SDT-759-13 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| IHC-P | 1:1000 | null |
| ICC | 1:500 | null |
Background
Fascin, also known as 55 kDa actin-bundling protein, is an intracellular 55-58 kDa member of the fascin family of proteins. It has a restricted expression pattern, being found in oligodendrocytes, select endothelium, cerebellar stellate neurons, and blood. Fascin is found associated with actin in filopodia, and serves to coordinate and stabilize actin bundle formation, both in normal cells and tumor cells. Fascin expression is highly upregulated in many types of carcinomas including breast, colon, gastric, and oral squamous cell carcinomas. In these cancers, increased Fascin expression is linked to increased aggressiveness and high mortality. Thus, Fascin is a common biomarker for aggressive carcinomas, can be used as a histological marker of particular cancer subtypes, and may be a useful therapeutic target.
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